PDK1 Proteins, Antibodies, cDNA Clones Research Reagents

PDK1 (Pyruvate Dehydrogenase Kinase 1) is a protein coding gene located on human chromosome 2q31.1. The human PDK1 gene encodes a 49244 Da protein containing 436 amino acids. The PDK1 protein is ubiquitously expressed in heart, adrenal and other tissues. Among its related pathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Signaling by GPCR. PDK1 is related to protein kinase activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. PDK3 is an important paralog of PDK1 gene. PDK1 is associated with some diseases, including Hypoxia and Chronic Mountain Sickness.

PDK1 Protein (1)

    PDK1 Antibody (2)

      PDK1 cDNA Clone (15)

      PDK1 qPCR Primer (1)

      PDK1 Lysate (1)

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        PDK1 Background

        Pyruvate dehydrogenase kinase, isozyme 1, also known as [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial and PDK1, is a member of the PDK / BCKDK protein kinase family. PDK-1 is expressed predominantly in the heart. It contains one histidine kinase domain. Pyruvate dehydrogenase kinase (PDK) isoforms are molecular switches that downregulate the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation in mitochondria. An inhibitory effect of lipoic acid on PDKs would result in less phosphorylation of E1 and hence increased PDC activity. At least two isoenzymic forms of pyruvate dehydrogenase kinase ( PDK-1 and PDK-2 ) may be involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase complex by phosphorylation. PDK-3 appears to have the highest specific activity among the three isoenzymes. PDK-1 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

        PDK1 References

        • Gudi R., et al., 1995, J. Biol. Chem. 270:28989-94.
        • Mooney,B.P. et al., 2000, Biochem Biophys Res Commun. 267 (2): 500 - 503.
        • Korotchkina,L.G. et al., 2004, Free Radic Res. 38 (10):1083-92.
        • Kato M., et al., 2007, Structure 15: 992-1004.

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