PCSK9 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) is a protein coding gene located on human chromosome 1p32.3. PCSK9 is also known as FH3, PC9, FHCL3, NARC1, LDLCQ1, NARC-1 and HCHOLA3. The human PCSK9 gene encodes a 74286 Da protein containing 692 amino acids. The PCSK9 protein is biasedly expressed in lung, liver and other tissues. Among its related pathways are Neuroscience and Lipoprotein metabolism. PCSK9 is related to protein self-association. MBTPS1 is an important paralog of PCSK9 gene. PCSK9 is associated with some diseases, including Hypercholesterolemia, Familial, 3 and Familial Hypercholesterolemia.

PCSK9 Protein (15)

    PCSK9 Antibody (22)

      PCSK9 ELISA Kit & Match Antibody ELISA Pair Set (6)

      PCSK9 cDNA Clone (39)

      NM_174936.3
      NM_153565.2
      NM_199253.2

      PCSK9 Lysate (10)

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        PCSK9 Background

        Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

        PCSK9 References

        • Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933.
        • Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498
        • Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73.
        • Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875.
        • Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.

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