PBK/TOPK Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PBK (PDZ Binding Kinase) is a protein coding gene located on human chromosome 8p21.1. PBK is also known as SPK, CT84, TOPK, HEL164, and Nori-3. The human PBK gene encodes a 36085 Da protein containing 322 amino acids. The PBK protein is biasedly expressed in testis, lymph node and other tissues. Among its related pathways are 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression and DNA Damage. PBK is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. PBK is associated with some diseases, including Plexiform Neurofibroma and Central Corneal Ulcer.

PBK/TOPK Protein (1)

    PBK/TOPK Antibody (4)

      PBK/TOPK ELISA Kit & Match Antibody ELISA Pair Set (1)

      PBK/TOPK cDNA Clone (30)

      PBK/TOPK Lysate (1)

        PBK/TOPK Background

        PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. This mitotic kinase phosphorylates MAP kinase p38 and seems to be active in mitosis. When phosphorylated, PBK forms a protein-protein interaction with tumor suppressor p53 (TP53), leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. The expression level of PBK is thus upregulated in a variety of neoplasms including hematological malignancies.

        PBK/TOPK References

        • Zakut-Houri R., et al.,(1985), Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4:1251-1255.
        • Lamb P., et al., (1986), Characterization of the human p53 gene.Mol. Cell. Biol. 6:1379-1385.
        • Harlow E., et al.,(1985), Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.Mol. Cell. Biol. 5:1601-1610.

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