Parathyroid Hormone/PTH Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All Parathyroid Hormone/PTH reagents are produced in house and quality controlled, including 3 Parathyroid Hormone/PTH Antibody, 1 Parathyroid Hormone/PTH ELISA, 13 Parathyroid Hormone/PTH Gene, 1 Parathyroid Hormone/PTH Lysate, 2 Parathyroid Hormone/PTH Protein. All Parathyroid Hormone/PTH reagents are ready to use.

Parathyroid Hormone/PTH Protein (2)

    Parathyroid Hormone/PTH Antibody (3)

      Parathyroid Hormone/PTH ELISA Kit & Match Antibody ELISA Pair Set (1)

      Parathyroid Hormone/PTH cDNA Clone (13)

      NM_000315.2

      Parathyroid Hormone/PTH Lysate (1)

        Parathyroid Hormone/PTH Background

        Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide. PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Parathyroid hormone (PTH) has been proved to play a pivotal role in maintaining myocardial contractility as well as effective natriuresis, and possible pathogenic mechanisms contributing to heart failure secondary to hypocalcemia and hypoparathyroidism. With the increased population of preosteoblastic lineages and the osteoblastic activation, Parathyroid hormone (PTH) drives anabolism in bone. Experiments have recently reported that PTH affects bone cells in a dual pathway - mediating osteoblastic (preosteoblastic) activities or osteocytic synthesis of sclerostin. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps.

        Parathyroid Hormone/PTH References

        • Bedi B, et al. (2012) Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH. Proc Natl Acad Sci U S A. 109(12): 725-33.
        • Hasegawa T, et al. (2012) Parathyroid hormone as a Bone anabolic agent. Biological function of bone cells on the PTH-driven anabolic effect. Clin Calcium. 22(3): 373-9.
        • Ito M. Parathyroid hormone as a Bone anabolic agent. Effect of PTH on bone structural properties. Clin Calcium. 22(3): 335-41.

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