OX40L/TNFSF4 Proteins, Antibodies, cDNA Clones Research Reagents

TNFSF4 (TNF Superfamily Member 4) is a protein coding gene located on human chromosome 1q25.1. TNFSF4 is also known as GP34, CD252, OX4OL, TXGP1, CD134L, OX-40L and TNLG2B. The human TNFSF4 gene encodes a 21050 Da protein containing 183 amino acids. Among its related pathways are PEDF Induced Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. TNFSF4 is related to signaling receptor binding and tumor necrosis factor receptor binding. TNFSF4 is associated with some diseases, including Myocardial Infarction and Systemic Lupus Erythematosus.

OX40L/TNFSF4 Protein (6)

    OX40L/TNFSF4 Antibody (1)

      OX40L/TNFSF4 cDNA Clone (52)


      OX40L/TNFSF4 Lysate (6)

        OX40L/TNFSF4 Background

        OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX40. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

        OX40L/TNFSF4 References

        • Lei W. et al., 2012, Ann Acad Med Singapore. 41 (5): 200-4.
        • Lee YH. et al., 2012, Hum Immunol. 73 (10): 1050-4.
        • Weiguang Y. et al., 2012, PLoS One. 7 (8): e41277.

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