OX40 Proteins, Antibodies, cDNA Clones Research Reagents

TNFRSF4 (TNF Receptor Superfamily Member 4) is a protein coding gene located on human chromosome 1p36.33. TNFRSF4 is also known as OX40, ACT35, CD134, IMD16, and TXGP1L. The human TNFRSF4 gene encodes a 29341 Da protein containing 277 amino acids. The TNFRSF4 protein is broadly expressed in fat, lymph node and other tissues. Among its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling. TNFRSF4 is related to tumor necrosis factor-activated receptor activity. TNFRSF1B is an important paralog of TNFRSF4 gene. TNFRSF4 is associated with some diseases, including Immunodeficiency 16 and Acute Graft Versus Host Disease.

OX40 Protein (10)

    OX40 Antibody (6)

      OX40 cDNA Clone (51)


      OX40 Lysate (9)

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        OX40 Background

        OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.

        OX40 References

        • Compaan D.M., et al. (2006) .The crystal structure of the costimulatory OX40-OX40L complex. Structure 14:1321-1330.
        • Kawamata S., et al. (1998) .Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. J. Biol. Chem. 273:5808-5814.
        • Byun M., (2013) Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J. Exp. Med. 210:1743-1759.

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