Osteoprotegerin Proteins, Antibodies, cDNA Clones Research Reagents

TNFRSF11B (TNF Receptor Superfamily Member 11b) is a protein coding gene located on human chromosome 8q24.12. TNFRSF11B is also known as OPG, TR1, OCIF and PDB5. The human TNFRSF11B gene encodes a 46026 Da protein containing 401 amino acids. The TNFRSF11B protein is biasedly expressed in thyroid, kidney and other tissues. Among its related pathways are Monoamine Transport and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. TNFRSF11B is related to cytokine activity. TNFRSF21 is an important paralog of TNFRSF11B gene. TNFRSF11B is associated with some diseases, including Paget Disease Of Bone 5, Juvenile-Onset and Bone Disease.

Osteoprotegerin Protein (4)

    Osteoprotegerin Antibody (4)

      Osteoprotegerin cDNA Clone (39)


      Osteoprotegerin Lysate (4)

        Osteoprotegerin Background

        Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.

        Osteoprotegerin References

        • Collin-Osdoby P. (2005) Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 95 (11): 1046-57.
        • Boyce BF, et al. (2007) Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 9 Suppl 1: S1.
        • Blázquez-Medela AM, et al. ( 2011) Osteoprotegerin and diabetes-associated pathologies. Curr Mol Med. 11 (5): 401-16.

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