NSFL1C Antibodies, cDNA Clones Research Reagents

NSFL1C (NSFL1 Cofactor, also known as P47; UBX1; UBXD10; UBXN2C; dJ776F14.1), located on 20p13, is a Protein Coding gene. The gene produces a 40573 Da protein composed of 370 amino acids. N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. The p97/p47 complex is probably the active component in the fusion reaction that leads to cisternal regrowth. Researchers have determined that human p47 is encoded by a single exon.
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NSFL1C General Information

NSFL1C Antibody (1)

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    NSFL1C cDNA Clone (31)

    XM_006235254.1

    In cloning vector

    In cloning vector

    NSFL1C qPCR Primer (1)

    NSFL1C IP Kit (1)

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    NSFL1C Background

    NSFL1C (NSFL1 Cofactor) is a Protein Coding gene. The NSFL1C gene, located on 20p13, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice. N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. The related pathways of NSFL1C are Protein processing in the endoplasmic reticulum.

    NSFL1C References

    • Zhang X, et al. (2015) Altered cofactor regulation with disease-associated p97/vcp mutations. Proc Natl Acad Sci U S A 112 (14): E1705-1714.
    • Park ES, et al. (2017) The opposite role of two uba-ubx containing proteins, p47 and saks1 in the degradation of a single erad substrate, α-tcr. Mol Cell Biochem 425 (1-2): 37-45.
    • Kondo H, et al. (1997) P47 is a cofactor for p97-mediated membrane fusion. Nature 388 (6637): 75-78.

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