NOTCH2 Proteins, Antibodies Research Reagents

NOTCH2 (Notch Receptor 2, also known as hN2; AGS2; HJCYS), located on 1p12, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 265405 Da protein composed of 2471 amino acids. The NOTCH2 gene encodes a single-pass transmembrane protein belonging to an evolutionarily conserved NOTCH receptor family. It is ubiquitously expressed in the testis, ovary, and other tissue. Diseases such as Alagille Syndrome 2 and Hajdu-Cheney Syndrome are associated with NOTCH2. The related pathways of NOTCH2 include Neuroscience and Signaling by GPCR.

NOTCH2 Protein (1)

    NOTCH2 Antibody (1)

      NOTCH2 qPCR Primer (1)

      NOTCH2 Lysate (1)

        NOTCH2 Background

        NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of developmental processes by controlling cell fate decisions. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced expression is associated with a less differentiated, more aggressive phenotype, and reduced overall survival. NOTCH2 has also been shown to have pro-apoptotic and growth-suppressive effects in thyroid carcinoma, and carcinoid tumors. NOTCH2 acts as an oncogene that promotes bladder cancer growth and metastasis through EMT, cell-cycle progression, and maintenance of stemness.

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