NKp46/NCR1 Proteins, Antibodies, cDNA Clones Research Reagents

All NKp46/NCR1 reagents are produced in house and quality controlled, including 2 NKp46/NCR1 Antibody, 39 NKp46/NCR1 Gene, 2 NKp46/NCR1 IP Kit, 2 NKp46/NCR1 Lysate, 2 NKp46/NCR1 Protein, 3 NKp46/NCR1 qPCR. All NKp46/NCR1 reagents are ready to use.

NKp46/NCR1 Protein (2)

    NKp46/NCR1 Antibody (2)

      NKp46/NCR1 cDNA Clone (39)


      NKp46/NCR1 Lysate (2)

        NKp46/NCR1 Background

        NCR1, also known as NK-p46 and CD335, is a natural cytotoxicity receptor(NCR). NCRs are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmic tail. All are expressed almost exclusively by NK cells and play a major role in triggering NK-mediated killing of most tumor cell lines. NKp46 has two extracellular Ig-like domains followed by a ~4 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium.

        NKp46/NCR1 References

        • Carbone E, et al. (2005) HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood. 105(1):251-8.
        • Sivori S, et al. (1997) p46, a Novel Natural Killer Cell-specific Surface Molecule That Mediates Cell Activation. J Exp Med. 186(7):1129-36.
        • Biassoni R, et al. (2004) Human natural killer cell receptors: insights into their molecular function and structure. J Cell Mol Med. 7(4):376-87.

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