NFkB1/p105 Antibodies, cDNA Clones Research Reagents

NFKB1 (Nuclear Factor Kappa B Subunit 1, also known as KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappa beta), located on 4q24, is a Protein Coding gene. This gene encodes a protein that can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The gene produces a 105356 Da protein composed of 968 amino acids. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli. Diseases such as Immunodeficiency, Common Variable, 12, and Common Variable Immunodeficiency are associated with NFKB1.

NFkB1/p105 Antibody (1)

    NFkB1/p105 cDNA Clone (15)

    NFkB1/p105 qPCR Primer (1)

    NFkB1/p105 Background

    NFKB1 (Nuclear Factor Kappa B Subunit 1) is a Protein Coding gene. This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Diseases associated with NFKB1 include Immunodeficiency, Common Variable, 12, and Common Variable Immunodeficiency. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Apoptosis Modulation and Signaling.

    NFkB1/p105 References

    • Lougaris V, et al. (2017) Nfkb1 regulates human nk cell maturation and effector functions. Clin Immunol 175 99-108.
    • Eluard B, et al. (2020) Nf-κb in the new era of cancer therapy. Trends Cancer 6 (8): 677-687.
    • Dieli-Crimi R, et al. (2018) Th1-skewed profile and excessive production of proinflammatory cytokines in a nfkb1-deficient patient with cvid and severe gastrointestinal manifestations. Clin Immunol 195 49-58.

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