NFAT2/NFATC1 Antibodies, cDNA Clones Research Reagents

NFATC1 (Nuclear Factor Of Activated T Cells 1, also known as NFAT2; NFATc; NF-ATC; NF-ATc1.2), located on 18q23, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 101243 Da protein composed of 943 amino acids. The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. Diseases such as Cherubism and Osteonecrosis are associated with NFATC1. The related pathways of NFATC1 include Nur77 Signaling in T-Cell and Signal transduction_JNK pathway.

NFAT2/NFATC1 Antibody (1)

    NFAT2/NFATC1 cDNA Clone (15)

    NFAT2/NFATC1 qPCR Primer (1)

    NFAT2/NFATC1 Background

    The nuclear factor of the activated T cell (NFAT) family of transcription factors regulates cytokine gene expression by binding to the promoter/enhancer regions of antigen-responsive genes, usually in cooperation with heterologous DNA-binding partners. The nuclear factor of activated T lymphocytes (NFATC1) signaling has been demonstrated to play important roles in cardiac valve and septal development. Genetic variants in genes involved in NFATC1 signaling may affect their expression and promote the formation of congenital heart disease (CHD). Nuclear factor of activated T cells (NFATC1) was up-regulated in cancers mediating malignant behaviors. The nuclear factor of activated T cell 1 (Nfatc1) locus is a common insertion site for murine tumorigenic retroviruses, suggesting a role of transcription factor NFATc1 in lymphomagenesis.

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