NF-kB p65 Proteins, Antibodies, cDNA Clones Research Reagents

RELA (RELA Proto-Oncogene, NF-KB Subunit) is a protein coding gene located on human chromosome 11q13.1. RELA is also known as p65, CMCU and NFKB3. The human RELA gene encodes a 60219 Da protein containing 551 amino acids. The RELA protein is ubiquitously expressed in bone marrow, spleen and other tissues. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Apoptosis Modulation and Signaling. RELA is related to DNA-binding transcription factor activity and identical protein binding. REL is an important paralog of RELA gene. RELA is associated with some diseases, including Mucocutaneous Ulceration, Chronic and Rela Fusion-Positive Ependymoma.

NF-kB p65 Protein (1)

    NF-kB p65 Antibody (2)

      NF-kB p65 cDNA Clone (30)

      NF-kB p65 qPCR Primer (1)

      NF-kB p65 Background

      RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an effective immune response but is also involved in the regulation of cell proliferation, development, and apoptosis. The implication of NF-kappaB in central biological processes and its extraordinary connectivity to other signaling pathways raise a need for highly controlled regulation of NF-kappaB activity at several levels. The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs to the control of immune responses and malignant transformation.

      NF-kB p65 References

      • Hashimoto R, et al. (2011) Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology. 36(9): 1921-31.
      • Vallabhapurapu S, et al. (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 27: 693-733.
      • Schmitz ML, et al. (2004) NF-kappaB: a multifaceted transcription factor regulated at several levels. Chembiochem. 5(10): 1348-58.

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