Nectin-2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

NECTIN2 (Nectin Cell Adhesion Molecule 2) is a protein coding gene located on human chromosome 19q13.32. NECTIN2 is also known as HVEB, PRR2, CD112, PVRL2, and PVRR2. The human NECTIN2 gene encodes a 57742 Da protein containing 538 amino acids. The NECTIN2 protein is ubiquitously expressed in placenta, testis and other tissues. Among its related pathways are Monoamine Transport and Cell junction organization. PVR is an important paralog of NECTIN2 gene. NECTIN2 is associated with some diseases, including Herpes Simplex and Cleft Lip/Palate-Ectodermal Dysplasia Syndrome.

Nectin-2 Protein (8)

    Nectin-2 Antibody (11)

      Nectin-2 ELISA Kit & Match Antibody ELISA Pair Set (2)

      Nectin-2 cDNA Clone (39)


      Nectin-2 Lysate (6)

        Nectin-2 Background

        Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

        Nectin-2 References

        • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
        • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.

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