NAALADL1 Proteins, Antibodies, cDNA Clones Research Reagents

All NAALADL1 reagents are produced in house and quality controlled, including 9 NAALADL1 Antibody, 14 NAALADL1 Gene, 2 NAALADL1 Lysate, 2 NAALADL1 Protein, 2 NAALADL1 qPCR. All NAALADL1 reagents are ready to use.

NAALADL1 Protein (2)

    NAALADL1 Antibody (9)

      NAALADL1 cDNA Clone (14)

      NM_005468.2

      In lentiviral vector

      NM_001009546.1

      NAALADL1 Lysate (2)

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        NAALADL1 Background

        N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidylpeptidase, is a Single-pass type I I membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. NAALADase L is a chloride-activated, membrane bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders.

        NAALADL1 References

        • Stauch BL. 1989, Neurosci Lett. 100 (1-3): 295-300.
        • Shneider BL. et al., 1997, J. Biol. Chem. 272: 31006-15.
        • Pangalos MN. et al., 1999, J. Biol. Chem. 274: 8470-83.
        • Thomas AG. et al., 1999, Brain Res. 843 (1-2): 48-52.

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