MTOR cDNA Clones Research Reagents

MTOR (Mechanistic Target Of Rapamycin Kinase, also known as SKS; FRAP; FRAP1; FRAP2; RAFT1; RAPT1), located on 1p36.22, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog. The gene produces a 288892 Da protein composed of 2549 amino acids. The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. Diseases such as Smith-Kingsmore Syndrome and Focal Cortical Dysplasia, Type Ii are associated with mTOR. The related pathways of MTOR include Translation Translation regulation by Alpha-1 adrenergic receptors and RET signaling.

MTOR cDNA Clone (2)

NM_004958.3

In lentiviral vector

In expression vector

MTOR qPCR Primer (1)

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MTOR Background

MTOR (Mechanistic Target Of Rapamycin Kinase) is a Protein Coding gene. The protein encoded by the MTOR gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. MTOR is a central regulator of cellular metabolism, growth, and survival in response to hormones, growth factors, nutrients, energy, and stress signals. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. MTOR is broadly expressed in the testis, brain, and other tissues. Diseases associated with MTOR include Smith-Kingsmore Syndrome and Focal Cortical Dysplasia, Type Ii. The ANGPTL7 gene is located in an intron of this gene.

MTOR References

  • Zhao J, Zhai B, Gygi SP, Goldberg AL. mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(52):15790-15797.

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