MICB Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All MICB reagents are produced in house and quality controlled, including 9 MICB Antibody, 2 MICB ELISA, 13 MICB Gene, 2 MICB Lysate, 2 MICB Protein, 1 MICB qPCR. All MICB reagents are ready to use.

MICB Protein (2)

    MICB Antibody (9)

      MICB ELISA Kit & Match Antibody ELISA Pair Set (2)

      MICB cDNA Clone (13)

      NM_005931.2

      MICB qPCR Primer (1)

      MICB Lysate (2)

        MICB Background

        MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related protein, both of which contain three extracellular immunoglobulin-like domains, but without capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen, binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells, CD8+αβ T cells, and γδ T cells on which the receptor is expressed. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance, viral infections, and autoimmune diseases.

        MICB References

        • Bauer, S. et al., 1999, Science. 285:727-729.
        • Braud, V.M. et al., 1999, Curr. Opin. Immunol. 11: 100-108.
        • Groh, V. et al., 2001, Nature Immunol. 2: 255-260.
        • Stephens, H., 2001, Trends Immunol. 22: 378-385.
        • Borrego, F. et al., 2002, Mol. Immunol. 38: 637–660.
        • Groh, V. et al., 2002, Nature. 419:734-738.

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