MICA Proteins, Antibodies, cDNA Clones Research Reagents

MICA (MHC Class I Polypeptide-Related Sequence A, also known as MIC-A; PERB11.1), located on 6p21.33, is a Protein Coding gene. The gene produces a 42915 Da protein composed of 383 amino acids. This gene encodes the highly polymorphic major histocompatibility complex class I chain-related protein A. It is further distinguished by its unusual exon-intron organization and preferential expression in fibroblasts and epithelial cells. Diseases such as Spondylitis and Psoriatic Arthritis are associated with MICA. The related pathways of MICA include the Immune response Role of DAP12 receptors in NK cells and Allograft rejection.

MICA Protein (5)

    MICA Antibody (5)

      MICA cDNA Clone (13)

      BC016929

      MICA qPCR Primer (1)

      MICA Lysate (5)

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        MICA Background

        MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to the MHC class I family. It is the member of the non-classical class I family that displays the greatest degree of polymorphism. The MICA protein product is expressed on the cell surface, although unlike canonical class I molecules do not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. The Natural killer group 2D (NKG2D), a C-type lectin-like activating immunoreceptor, is a receptor of MICA, which was detected on most gamma-delta T cells, CD8+ alpha-beta T cells, and natural killer (NK) cells. Effector cells from all these subsets could be stimulated by the ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gamma-delta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. The MICA system is a novel, avidin-free immunohistochemical detection system that provides a significant increase in sensitivity compared to traditional immunodetection systems.

        MICA References

        • Choy MK, et al. (2010) MICA polymorphism: biology and importance in immunity and disease. Trends Mol Med. 16(3): 97-106.
        • Li J, et al. (2005) Distinct pattern of human Vdelta1 gammadelta T cells recognizing MICA. Cell Mol Immunol. 2(4): 253-8.
        • Mangham DC, et al. (2000) MICA-a highly sensitive and avidin-free immunohistochemical detection system. Adv Anat Pathol. 7(6): 360-4.
        • Bauer S, et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 285(5428): 727-9.
        • Groh V, et al. (1998) Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. Science. 279: 1737-40.

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