MD2/LY96 Proteins, cDNA Clones Research Reagents

All MD2/LY96 reagents are produced in house and quality controlled, including 26 MD2/LY96 Gene, 1 MD2/LY96 Lysate, 1 MD2/LY96 Protein, 2 MD2/LY96 qPCR. All MD2/LY96 reagents are ready to use.

MD2/LY96 Protein (1)

    MD2/LY96 cDNA Clone (26)


    MD2/LY96 Lysate (1)

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      MD2/LY96 Background

      LY-96, also known as ESOP-1, is a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS). LY-96 also cooperates with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. It enhances TLR4-dependent activation of NF-kappa-B. ESOP-1 has 16 amino acids, the sequence of which shows 64% identity with human ESOP-1/MD-2. ESOP-1 mRNA is highly expressed in the mouse embryos at 7.5 days after coitus.

      MD2/LY96 References

      • Shimazu R., et al.,(1999), MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189:1777-1782.
      • Kato K., et al., (2000), ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice.Blood 96:362-364.
      • Schromm A.B., et al.,(2001), Molecular genetic analysis of an endotoxin nonresponder mutant cell line. A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.J. Exp. Med. 194:79-88.

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