MART-1/MLANA Antibodies, cDNA Clones Research Reagents

MLANA (Melan-A, also known as MART1; MART-1), located on 9p24.1, is a Protein Coding gene. The gene produces a 13157 Da protein composed of 118 amino acids. MLANA is a hydrophobic transmembrane protein without glycosylation sites highly enriched in early melanosomes. MLANA is expressed in skin and retinae melanocytes and the majority of melanoma tumors, but it is absent from other tissues and tumors. Diseases such as Melanoma In Congenital Melanocytic Nevus and Angiomyolipoma are associated with MLANA. The related pathways of MLANA include NF-kappaB Signaling.
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All MART-1/MLANA Reagents

MART-1/MLANA General Information

MART-1/MLANA Antibody (1)

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    MART-1/MLANA cDNA Clone (15)

    MART-1/MLANA qPCR Primer (1)

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    MART-1/MLANA Background

    MART-1 is a hydrophobic transmembrane protein without glycosylation sites highly enriched in early melanosomes. MART-1 is necessary for gp1 function, another antigen associated with cutaneous melanoma, involved in the regulation of melanosome formation. MART-1 is expressed in skin and retinae melanocytes and the majority of melanoma tumors, but it is absent from other tissues and tumors. It was isolated thanks to the specific recognition by T lymphocytes of MART-1 derived peptides, especially in the context of the HLA-A21 haplotype, present in tumor infiltrates from melanoma patients. Thus, MART-1 is immunogenic in humans and has been widely exploited to induce anti-melanoma immunity in patients through several vaccination strategies.

    MART-1/MLANA References

    • Barrio MM, Abes R, Colombo M, et al. Human Macrophages and Dendritic Cells Can Equally Present MART-1 Antigen to CD8+ T Cells after Phagocytosis of Gamma-Irradiated Melanoma Cells. Chatenoud L, ed. PLoS ONE. 2012;7(7):e40311.

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