MAPKAPK3 Proteins, Antibodies, cDNA Clones Research Reagents

All MAPKAPK3 reagents are produced in house and quality controlled, including 2 MAPKAPK3 Antibody, 30 MAPKAPK3 Gene, 1 MAPKAPK3 Lysate, 1 MAPKAPK3 Protein, 2 MAPKAPK3 qPCR. All MAPKAPK3 reagents are ready to use.

MAPKAPK3 Protein (1)

    MAPKAPK3 Antibody (2)

      MAPKAPK3 cDNA Clone (30)

      MAPKAPK3 Lysate (1)

        More Product Popular With Customers

        MAPKAPK3 Background

        The MAPKAP kinases are a group of MAP kinase substrates which are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases. Mitogen-activated protein (MAP) kinase-activated protein kinase 3, also known as MAPKAPK-3 and 3pK, is a member of the Ser/Thr protein kinase family. It is Widely expressed in human tissues, with a higher expression level observed in heart and skeletal muscle. No expression in brain. MAPKAPK-3 is unique since it was shown to be activated by three members of the MAPK family, namely extracellular-signal-regulated kinase (ERK), p38, and Jun-N-terminal kinase (JNK). It is highly activated both by mitogens and by stress-inducing agents or proinflammatory cytokines, and translocates to the cytoplasm from nucleus. MAPKAPK-3 is exclusively activated via the classical MAPK cascade, while stress-induced activation of MAPKAPK-3 is mainly mediated by p38, however the mechanism defining the specificity remains unknown.

        MAPKAPK3 References

        • McLaughlin, M.M. et al., 1996, J. Biol. Chem. 271:8488-8492.
        • Tanoue, T. et al., 2001, EMBO J. 20: 466-479.
        • Neufeld, B. et al., 2000, J. Biol. Chem. 275: 20239-20242.
        • Zakowski,V. et al., 2004, Exp Cell Res. 299: 101-109.
        • Voncken, J. W. et al., 2005, J. Biol. Chem. 280: 5178-5187.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.