The p38 kinases are one of the four subgroups of the mitogen-activated protein kinase (MAPK) superfamily which are involved in innate immunity. The p38 subfamily includes four members namely p38alpha (MAPK14), p38beta (MAPK11), p38gamma (MAPK12), and p38delta (MAPK13), regulates the activation of several transcription factors. MAPK11 (Mitogen-Activated Protein Kinase 11) is a Protein Coding gene. This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. MAPK11 is widely expressed in fat, the brain, and other tissues. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen-activated protein kinase kinases (MKKs).