MAP3K8 Proteins, Antibodies, cDNA Clones Research Reagents

All MAP3K8 reagents are produced in house and quality controlled, including 1 MAP3K8 Antibody, 30 MAP3K8 Gene, 1 MAP3K8 Lysate, 1 MAP3K8 Protein, 2 MAP3K8 qPCR. All MAP3K8 reagents are ready to use.

MAP3K8 Protein (1)

    MAP3K8 Antibody (1)

      MAP3K8 cDNA Clone (30)

      MAP3K8 Lysate (1)

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        MAP3K8 Background

        Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein which belongs to theprotein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase kinase subfamily. MAP3K8 is expressed in several normal tissues and human tumor-derived cell lines. Isoform1of MAP3K8 is activated specifically during the S and G2/M phases of the cell cycle. MAP3K8 is required for TLR4 activation of the MEK/ERK pathway. It is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p15. MAP3K8 plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein. MAP3K8 oncogene linked to human endometrial carcinoma suggesting that it may be another molecule involved in human endometrial cancer. MAP3K8 may also be an important mediator of intracellular mechanotransduction in human bone marrow-derived mesenchymal stem cells (MSCs).

        MAP3K8 References

        • Clark,A.M. et al., 2004, Genes Chromosomes Cancer. 41 (2):99-108.
        • Chan,H. et al., 2005, Biochem Biophys Res Commun. 328 (1):198-205.
        • Aparecida Alves,C. et al., 2006, Eur J Gynaecol Oncol. 27 (6):589-93.
        • Mielke,L.A. et al., 2009, J Immunol. 183 (12):7984-93.
        • Glossop,J.R. et al., 2009,Gene Expr Patterns  9 (5):381-8. 

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