MAP1D Proteins, Antibodies, cDNA Clones Research Reagents

All MAP1D reagents are produced in house and quality controlled, including 5 MAP1D Antibody, 30 MAP1D Gene, 1 MAP1D Lysate, 1 MAP1D Protein, 2 MAP1D qPCR. All MAP1D reagents are ready to use.

MAP1D Protein (1)

    MAP1D Antibody (5)

      MAP1D cDNA Clone (30)

      MAP1D Lysate (1)

        MAP1D Background

        Methionine aminopeptidase 1D, also known as MAP1D, is a member of thepeptidase M24A family. N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localization, and eventual degradation of many proteins. The enzymes that catalyze this reaction are called Methionine aminopeptidases (MAPs). MAP1D is overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level). Downregulation of MAP1D expression by shRNA in HCT-116 colon carcinoma cells reduces anchorage-independant growth in soft agar. MAP1D binds two cobalt ions per subunit. The true nature of the physiological cofactor is under debate. MAP1D is also active with zinc, manganese or divalent ions. MAP1D removes the amino-terminal methionine from nascent proteins. It may also play an important role in colon tumorigenesis.

        MAP1D References

        • Serero A., et al.,(2003), An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway. J. Biol. Chem. 278:52953-52963.
        • Leszczyniecka M., et al., (2006), MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer.Oncogene 25:3471-3478.
        • Vaca Jacome A.S., et al.,(2015), N-terminome analysis of the human mitochondrial proteome.Proteomics 15:2519-2524.

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