LYRIC cDNA Clones Research Reagents

MTDH (Metadherin, also known as 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3), located on 8q22.1, is a Protein Coding gene. The gene produces a 63837 Da protein composed of 582 amino acids. The protein has an N-terminal transmembrane region, 2 nuclear localization sequences, a potential ATP/GTP-binding site, and some putative phosphorylation sites. Diseases such as Tongue Carcinoma and Gallbladder Adenocarcinoma are associated with MTDH. The related pathways of MTDH include Gastric Cancer Network 2 and Validated targets of C-MYC transcriptional activation.

LYRIC cDNA Clone (5)

NM_178812.3

In cloning vector

In lentiviral vector

In expression vector

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LYRIC Background

Metadherin (MTDH), also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1), has emerged as an important oncogene protein that is overexpressed in all cancers analyzed so far. MTDH has been demonstrated to play a potential role in several significant aspects of tumor progression. The presence of the lung-homing domain of MTDH on tumor cells at the cell surface where it would be available to bind to vascular targets during metastasis has been confirmed. It has been reported that overexpression of MTDH is associated with the progression of the disease and a poorer prognosis in breast cancer. It has been reported that MTDH overexpression could significantly enhance the invasion and migration of breast cancer cells by inducing epithelial-mesenchymal transition (EMT) which is a process in which polarized epithelial cells are converted into motile mesenchymal cells. Thus, during cancer development, MTDH is conducive to tumor dissemination and metastatic spread.

LYRIC References

  • Yoo BK, et al. (2011) Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology. Pharmacol Ther.130 (1) : 1-8.
  • Li XY, et al. (2011) Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Science. 102 (6) : 1151-7.
  • Su P, et al. (2010) Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue. Diagnostic Pathology. 5: 38.

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