LYPD3 Proteins, Antibodies, cDNA Clones Research Reagents

LYPD3 (LY6/PLAUR Domain Containing 3, also known as C4.4A), located on 19q13.31, is a Protein Coding gene. The gene produces a 35971 Da protein composed of 346 amino acids. The protein shares 81.8% amino acid identity with rat C4.4a and has 6 N-glycosylation sites and a potential glycosylphosphatidylinositol (GPI)-anchoring sequence. Diseases such as Atrial Septal Defect 6 and Mal De Meleda are associated with LYPD3. The related pathways of LYPD3 include the Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

LYPD3 Protein (2)

    LYPD3 Antibody (6)

      LYPD3 cDNA Clone (26)


      LYPD3 Lysate (2)

        LYPD3 Background

        Ly6 / PLAUR domain-containing protein 3, also known as GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4, and LYPD3, is a cell membrane protein that contains two UPAR/Ly6 domains. Human LYPD3 contains two UPAR/Ly6 domains. LYPD3 is expressed in the placenta, skin, and urothelium. It is found in suprabasal keratinocytes of chronic wounds. Weak expression of LYPD3 is found in the esophagus and peripheral blood mononuclear cells. It is found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression of LYPD3 is found in the tumor component of some noninvasive superficial lesions and invasive and metastatic urothelial cancers. LYPD3 is up-regulated in migrating keratinocytes during epithelisation of incisional skin wounds. LYPD3 supports cell migration. It may be involved in urothelial cell-matrix interactions. It may also be involved in tumor progression

        LYPD3 References

        • Smith B.A., et al., 2001, Cancer Res. 61:1678-85.
        • Wuerfel J., et al., 2001, Gene 262:35-41.
        • Clark H.F., et al., 2003, Genome Res. 13:2265-70.
        • Fletcher G.C., et al., 2003, Br. J. Cancer 88:579-85.
        • Hansen L.V., et al., 2004, Biochem. Eng. J. 380:845-57.

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