LRP10 Proteins, Antibodies, cDNA Clones Research Reagents

LRP10 (LDL Receptor Related Protein 10, also known as LRP9; LRP-10; MST087; MSTP087), located on 14q11.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog. The gene produces a 76193 Da protein composed of 713 amino acids. This gene encodes a low-density lipoprotein receptor family protein. Diseases such as Ovarian Embryonal Carcinoma and Angiostrongyliasis are associated with LRP10. The related pathways of LRP10 include Signaling by GPCR and Metabolism of fat-soluble vitamins.

LRP10 Protein (2)

    LRP10 Antibody (1)

      LRP10 cDNA Clone (13)


      LRP10 Lysate (2)

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        LRP10 Background

        LRP10 (low-density lipoprotein Receptor Related Protein 10) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a low-density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. Human LRP10 cDNA encodes a 1905 amino acid type I membrane protein consisting of five functional domains characteristic of the LDLR gene family. It is widely expressed in the esophagus, colon, and other tissues. LRP10 plays a significant role in brain physiology other than lipoprotein metabolism. It is associated with a series of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease which share genetic risk factors and pathophysiological processes with amyotrophic lateral sclerosis (ALS).

        LRP10 References

        • Jeong YH, et al. (2010) The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway. Biochem Biophys Res Commun. 392(4): 495-9.
        • Beisiegel U, et al. (1991) Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A. 88(19): 8342-6.
        • Strickland DK, et al. (1990) Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem. 265(29): 17401-4.

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