LRP1 Antibodies Research Reagents

LRP1 (LDL Receptor Related Protein 1, also known as APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; IGFBP-3R; IGFBP3R1), located on 12q13.3, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog. The gene produces a 504606 Da protein composed of 4544 amino acids. This gene encodes a member of the low-density lipoprotein receptor family of proteins. Diseases such as Keratosis Pilaris Atrophicans and Atrophoderma Vermiculata are associated with LRP1. The related pathways of LRP1 include Neuroscience and Signaling by GPCR.

LRP1 Antibody (1)

    LRP1 qPCR Primer (1)

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    LRP1 Background

    Low-density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER), or cluster of differentiation 91 (CD91), is an endocytic receptor involved in several cellular processes. LRP1 / CD91 is a member of the cluster of differentiation (CD) system. The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins do not take part in the cell signal process but have other functions such as cell adhesion. LRP1 / CD91 is involved in endocytosis and phagocytosis of apoptotic cells and is required for early embryonic development. LRP1 / CD91 is also involved in cellular lipid homeostasis, the plasma clearance of chylomicron remnants, activated LRPAP1 (alpha 2-macroglobulin), and the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. LRP1 / CD91 May modulate cellular events, such as APP metabolism kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission need the involvement of LRP1 / CD91.

    LRP1 References

    • Su HP, et al. (2002) Interaction of CED-6 / GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91 / low density lipoprotein receptor-related protein (LRP). J Biol Chem. 277(14): 11772-9.
    • Chen JS, et al. (2010) Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91 / LRP-1 and NF-kappaB-mediated integrin alphaV expression. J Biol Chem. 285(33): 25458-66.
    • Dasgupta S, et al. (2008) Factor VIII bypasses CD91 / LRP for endocytosis by dendritic cells leading to T-cell activation. Haematologica. 93(1): 83-9.

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