LRIG1 Proteins, Antibodies, cDNA Clones Research Reagents

LRIG1 (Leucine-Rich Repeats And Immunoglobulin Like Domains 1, also known as LIG1; LIG-1), located on 3p14.1, is a Protein Coding gene. The gene produces a 119113 Da protein composed of 1093 amino acids. LRIG1 has 6 potential N-glycosylation sites. Mouse and human LRIG1 share 83% amino acid identity, with the highest conservation in the extracellular, transmembrane, and membrane-proximal regions. Diseases such as Verrucous Carcinoma and Hyaline Fibromatosis Syndrome are associated with LRIG1. The related pathways of LRIG1 include RET signaling and Signaling by GPCR.

LRIG1 Protein (1)

    LRIG1 Antibody (2)

      LRIG1 cDNA Clone (26)

      NM_015541.2
      NM_008377.2

      LRIG1 qPCR Primer (1)

      LRIG1 Lysate (1)

        LRIG1 Background

        Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine kinases. Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit the growth of different types of malignancies. Leucine-rich repeats and immunoglobulin-like domains 1(LRIG1)is a kind of transmembrane glycoprotein, which is induced by epidermal growth factor (EGF) and develops inhibitory negative feedback by specific binding with epidermal growth factor receptor (EGFR). LRIG1 expression is broadly decreased in human cancer and breast cancer and low expression of LRIG1 has been linked to decreased relapse-free survival.

        LRIG1 References

        • Shattuck DL, et al. (2007) LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy. Mol Cell Biol. 27 (5): 1934-46.
        • Ledda F, et al. (2008) Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF. J Neurosci. 28(1): 39-49.
        • Hedman H, et al. (2002) Is LRIG1 a tumour suppressor gene at chromosome 3p14.3 Acta Oncol. 41(4): 352-4.

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