LOXL2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All LOXL2 reagents are produced in house and quality controlled, including 3 LOXL2 Antibody, 1 LOXL2 ELISA, 13 LOXL2 Gene, 3 LOXL2 Lysate, 3 LOXL2 Protein, 1 LOXL2 qPCR. All LOXL2 reagents are ready to use.

LOXL2 Protein (3)

    LOXL2 Antibody (3)

      LOXL2 ELISA Kit & Match Antibody ELISA Pair Set (1)

      LOXL2 cDNA Clone (13)


      LOXL2 qPCR Primer (1)

      LOXL2 Lysate (3)

        LOXL2 Background

        Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein which belongs to thelysyl oxidase family. LOXL2 contains fourSRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent propeptide regions. LOX family enzyme activities catalyze the final enzymatic conversion required for the formation of normal biosynthetic collagen and elastin cross-links. LOXL2 is expressed by pre-hypertrophic and hypertrophic chondrocytes in vivo, and that LOXL2 expression is regulated in vitro as a function of chondrocyte differentiation. LOXL2 promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation. LOXL2 expression could also be explored as a molecular target in the prevention of breast cancer progression.

        LOXL2 References

        • Peng,L. et al., 2009, Carcinogenesis. 30 (10):1660-9.
        • Hollosi,P. et al., 2009, Int J Cancer. 125 (2):318-27.
        • Rückert,F. et al., 2010, Int J Colorectal Dis. 25 (3):303-11.
        • Iftikhar,M. et al., 2011, J Biol Chem. 286 (2):909-18.

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