LIMPII/SR-B2 Proteins, Antibodies, cDNA Clones Research Reagents

SCARB2 (Scavenger Receptor Class B Member 2) is a protein coding gene located on human chromosome 4q21.1. SCARB2 is also known as AMRF, EPM4, LGP85, CD36L2, HLGP85, LIMP-2, LIMPII and SR-BII. The human SCARB2 gene encodes a 54290 Da protein containing 478 amino acids. The SCARB2 protein is ubiquitously expressed in brain, prostate and other tissues. Among its related pathways are Lysosome and Clathrin-mediated endocytosis. SCARB2 is related to enzyme binding. CD36 is an important paralog of SCARB2 gene. SCARB2 is associated with some diseases, including Epilepsy, Progressive Myoclonic, 4, With Or Without Renal Failure and Unverricht-Lundborg Syndrome.

LIMPII/SR-B2 Protein (3)

    LIMPII/SR-B2 Antibody (8)

      LIMPII/SR-B2 cDNA Clone (39)

      NM_005506.2
      NM_007644.3
      NM_054001.2

      LIMPII/SR-B2 Lysate (3)

        LIMPII/SR-B2 Background

        Lysosomal Integral Membrane Protein II (LIMPII), also known as SCARB2, LPG85, and CD36L2, is a type I II multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. This protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. LIMPII is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Expression of human LIMPII enables normally unsusceptible cell lines to support the viruses’ propagation and develop cytopathic effects. In addition, LIMPII also has been shown to bind thrombospondin-1, and may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation. Deficiency of the protein in mice impairs cell membrane transport processes and causes pelvic junction obstruction, deafness, and peripheral neuropathy.

        LIMPII/SR-B2 References

        • Crombie, R. et al., 1998, J. Biol. Chem. 273: 4855-4863.
        • Febbraio, M. et al., 2001, J. Clin. Invest. 108: 785-791.
        • Kuronita, T. et al., 2002, J. Cell Sci. 115: 4117-4131.
        • Gamp, A.C. et al., 2003, Human Molecular Genetics. 12: 631-646.
        • Eskelinen, E.L. et al., 2003, Trends in Cell Biology. 13: 137-145.
        • Mulcahy, J.V. et al.,2004, Biochem. J. 377 (Pt 3): 741–747.
        • Yamayoshi, S. et al., 2009, Nat Med. 15 (7): 798-801.

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