LILRB1 Proteins, Antibodies, cDNA Clones Research Reagents

LILRB1 (Leukocyte Immunoglobulin Like Receptor B1, also known as ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B), located on 19q13.42, is a Protein Coding gene. The gene produces a 70819 Da protein composed of 650 amino acids. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. Diseases such as Alzheimer's Disease 12 and Severe Pre-Eclampsia are associated with LILRB1. The related pathways of LILRB1 include Innate Immune System and Class I MHC mediated antigen processing and presentation.

LILRB1 Protein (3)

    LILRB1 Antibody (5)

      LILRB1 cDNA Clone (2)


      In expression vector

      LILRB1 Lysate (2)

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        LILRB1 Background

        LILRB1 (Leukocyte Immunoglobulin Like Receptor B1) is a Protein Coding gene. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). LILRB1 is encoded within the leukocyte receptor complex on 19q13.4, previously implicated to be a susceptibility region to systemic lupus erythematosus (SLE). LILRB1 binds to a wide range of Major Histocompatibility Complex Class I molecules (MHCIs) and transduces negative signals that can, for example, prevent the killing of MHCI-expressing cells. LILRB1 transcription is correlated with surface protein expression on NK cells. Diseases associated with LILRB1 include Alzheimer's Disease 12 and Severe Pre-Eclampsia.

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