LIF Proteins, Antibodies, cDNA Clones Research Reagents

LIF (LIF Interleukin 6 Family Cytokine, also known as CDF; DIA; HILDA; MLPLI), located on 22q12.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. The gene produces a 22008 Da protein composed of 202 amino acids. The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. Diseases such as Leukemia and Myeloid Leukemia are associated with LIF. The related pathways of LIF include PEDF Induced Signaling and Apoptotic Pathways in Synovial Fibroblasts.

LIF Protein (5)

    LIF Antibody (5)

      LIF cDNA Clone (39)


      LIF Lysate (5)

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        LIF Background

        Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It is involved in growth promotion and cell differentiation of different types of target cells, influence bone metabolism, cachexia, neural development, embryogenesis, and inflammation. LIF has potent proinflammatory properties, being the inducer of the acute phase protein synthesis and affecting cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic, and neuronal cells. LIF binds to the specific LIF receptor (LIFR-α) which forms a heterodimer with a specific subunit common to all members of that family of receptors, the GP130 signal-transducing subunit. This leads to the activation of the JAK/STAT and MAPK cascades. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origins.

        LIF References

        • Salas EM, et al. (2011) LIF, a Novel STAT5-Regulated Gene, Is Aberrantly Expressed in Myeloproliferative Neoplasms. Genes Cancer. 2 (5): 593-6.
        • Chodorowska G, et al. (2004) Leukemia inhibitory factor (LIF) and its biological activity. Ann Univ Mariae Curie Sklodowska Med. 59 (2): 189-93.
        • Garcia-Campana AM, et al. (2007) LIF detection of peptides and proteins in CE. Electrophoresis. 28 (1-2): 208-32.

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