LCN1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All LCN1 reagents are produced in house and quality controlled, including 4 LCN1 Antibody, 1 LCN1 ELISA, 13 LCN1 Gene, 1 LCN1 Lysate, 1 LCN1 Protein, 1 LCN1 qPCR. All LCN1 reagents are ready to use.

LCN1 Protein (1)

    LCN1 Antibody (4)

      LCN1 ELISA Kit & Match Antibody ELISA Pair Set (1)

      LCN1 cDNA Clone (13)

      NM_002297.2

      LCN1 qPCR Primer (1)

      LCN1 Lysate (1)

        LCN1 Background

        Lipocalin-1, also known as Von Ebner gland protein, VEG protein, Tear prealbumin, VEGP, Tear lipocalin and LCN1, is a secreted protein which belongs to thecalycin superfamily and Lipocalin family. Human Lipocalin-1 / VEGP was originally described as a major protein of human tear fluid, which was thought to be tear specific. Lipocalin-1 / VEGP is identical with lingual von Ebner's gland protein, and is also produced in prostate, nasal mucosa and tracheal mucosa. Homologous proteins have been found in rat, pig and probably dog and horse. Lipocalin-1 / VEGP is an unusual lipocalin member, because of its high promiscuity for relative insoluble lipids and binding characteristics that differ from other members. Lipocalin-1 / VEGP acts as the principal lipid binding protein in tear fluid, a more general physiological function has to be proposed due to its wide distribution and properties. Lipocalin-1 / VEGP would be ideally suited for scavenging of lipophilic, potentially harmful substances and thus might act as a general protection factor of epithelia. Lipocalin-1 / LCN1 could play a role in taste reception. It could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Lipocalin-1 / LCN1 can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. It exhibits an extremely wide ligand pocket.

        LCN1 References

        • Lassagne H. et al., 1993, Exp. Eye Res. 56:605-609.
        • Redl,B. et al., 2000, Biochim Biophys Acta  1482 (1-2):241-8.
        • Wojnar P. et al., 2001, J. Biol. Chem. 276:20206-20212.
        • Wojnar P. et al., 2003, J. Biol. Chem. 278:16209-16215.
        • Breustedt D.A. et al., 2005, J. Biol. Chem. 280:484-493.

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