LAIR2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LAIR2 (Leukocyte Associated Immunoglobulin Like Receptor 2, also known as CD306), located on 19q13.42, is a Protein Coding gene. The gene produces a 16280 Da protein composed of 152 amino acids. The protein encoded by this gene is a member of the immunoglobulin superfamily. The predicted LAIR2 protein contains 1 immunoglobulin-like domain, which is 84% homologous to that of LAIR1; it lacks both a transmembrane and a cytoplasmic domain. The related pathways of LAIR2 include Innate Immune System and Class I MHC mediated antigen processing and presentation.

LAIR2 Protein (3)

    LAIR2 Antibody (4)

      LAIR2 ELISA Kit & Match Antibody ELISA Pair Set (2)

      LAIR2 cDNA Clone (13)


      LAIR2 qPCR Primer (1)

      LAIR2 Lysate (3)

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        LAIR2 Background

        Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD36, is a 131 amino acid protein containing one Ig-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.

        LAIR2 References

        • Meyaard, L. et al.,1997, Immunity.7:283-290.
        • Meyaard, L. et al.,1999, J. Immunol. 162:5800-5804.
        • Meyaard, L. et al., 2001,  J. Exp. Med. 194 (1): 107-112.
        • Meyaard, L., 2003, J Biol Regul Homeost Agents.  17 (4): 330-333.
        • Lebbink, R. J. et al., 2008, J Immunol. 180 (3):1662-1669.
        • Lebbink,R.J. et al., 2009,  Matrix Biol.  28 (4):202-210.

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