KIRREL Proteins, Antibodies, cDNA Clones Research Reagents

KIRREL1 (Kirre Like Nephrin Family Adhesion Molecule 1, also known as NEPH1; KIRREL), located on 1q23.1, is a Protein Coding gene. The gene produces an 83536 Da protein composed of 757 amino acids. KIRREL1 is a member of the nephrin-like protein family, which includes NEPH2 and NEPH3. KIRREL1 triggers AP-1 activation similarly to nephrin but requires the presence of Tec family kinases for efficient transactivation. The related pathways of KIRREL1 include Nephrin/Neph1 signaling in the kidney podocyte and Cell junction organization.

KIRREL Protein (3)

    KIRREL Antibody (1)

      KIRREL Lysate (3)

        More Product Popular With Customers

        KIRREL Background

        NEPH1 (KIRREL1) belongs to a family of three closely related transmembrane proteins of the Ig superfamily with a structure similar to that of nephrin. All three Neph proteins share a conserved podocin-binding motif; mutation of a centrally located tyrosine residue dramatically lowers the affinity of Neph1 for podocin. Neph1 triggers AP-1 activation similarly to nephrin but requires the presence of Tec family kinases for efficient transactivation. Neph1 consists of a signal peptide, five Ig-like C2-type domains with the middle domain overlapping with a PKD-like domain, an RGD sequence, a transmembrane domain, and a cytoplasmic tail, which is expressed in slit diaphragm domains of podocytes and vertebrate and invertebrate nervous systems. Neph1 is abundantly expressed in the kidney, specifically expressed in podocytes of kidney glomeruli, and plays a significant role in the normal development and function of the glomerular permeability. Neph1 interacts with nephrin in vitro and in vivo, and able to stimulate transcriptional activation in a model system, such as the activation of the transcription factor AP-1 via the stimulation of a MAPK module. Neph1 is crucial for the integrity of the slit diaphragm, as Neph1 gene knockout mice result in effacement of glomerular podocytes, heavy proteinuria, and early postnatal death.

        KIRREL References

        • Sellin L, et al. (2003) NEPH1 defines a novel family of podocin interacting proteins. FASEB J. 17(1): 115-7.
        • Kim EY, et al. (2009) Neph1 regulates steady-state surface expression of Slo1 Ca(2+)-activated K(+) channels: different effects in embryonic neurons and podocytes. Am J Physiol Cell Physiol. 297(6): C1379-88.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.