KIR2DL3 Proteins, Antibodies, cDNA Clones Research Reagents

KIR2DL3 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 3, also known as p58; NKAT; GL183; NKAT2; CD158b; KIR2DL; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GB), located on 19q13.42, is a Protein Coding gene. The gene produces a 37886 Da protein composed of 341 amino acids. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Diseases such as T-Cell Large Granular Lymphocyte Leukemia and Tropical Spastic Paraparesis are associated with KIR2DL3.

KIR2DL3 Protein (2)

    KIR2DL3 Antibody (3)

      KIR2DL3 cDNA Clone (13)

      BC032422

      KIR2DL3 qPCR Primer (1)

      KIR2DL3 Lysate (2)

        KIR2DL3 Background

        Killer cell immunoglobulin-like receptor 2DL3, also known as CD158 antigen-like family member B2, KIR-23GB, Killer inhibitory receptor cl 2-3, MHC class I NK cell receptor, NKAT2a, NKAT2b, Natural killer-associated transcript 2, p58 natural killer cell receptor clone CL-6, p58.2 MHC class-I-specific NK receptor, CD158b2, and KIR2DL3, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. KIR2DL3 contains 2 Ig-like C2-type (immunoglobulin-like) domains. KIR2DL3 interacts with ARRB2. KIR2DL3 is a receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3, and HLA-Cw7). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.

        KIR2DL3 References

        • Selvakumar A., et al., 1997, Immunol. Rev. 155:183-196.
        • Wilson M.J., et al., 1997, Tissue Antigens 49:574-579.
        • Maenaka K., et al., 1999, Structure 7:391-398.
        • Vitale,M. et al., 2004, Int Immunol. 16 (10):1459-66.
        • Yu M.-C., et al., 2008, Nat. Immunol. 9:898-907.

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