KAT1/HAT1 Antibodies, cDNA Clones Research Reagents

HAT1 (Histone Acetyltransferase 1, also known as KAT1), located on 2q31.1, is a Protein Coding gene. The gene produces a 49513 Da protein composed of 419 amino acids. The human HAT1 contains D, A, and B motifs, which are present in many N-acetyltransferases. HAT1 also contains a putative bipartite nuclear localization signal; however, deletion of this signal did not affect the intranuclear localization of HAT1. The related pathways of HAT1 include Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

KAT1/HAT1 Antibody (2)

    KAT1/HAT1 cDNA Clone (30)

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    KAT1/HAT1 Background

    HAT1 (Histone Acetyltransferase 1) is a Protein Coding gene. The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. HAT1 can up-regulate cell apoptosis. The dysfunction of apoptosis is one of the factors contributing to lung cancer (LC) growth. Upregulation of HAT1 expression in LCCs can induce LCCs apoptosis, which may be a potential novel therapy for the treatment of LC. KAT8 or HAT1 regulate HBV replication and may be potential drug targets of anti-HBV therapy. HAT1 played an important role in esophageal carcinoma and that it could be a novel EC therapeutic target.

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