Kallikrein 7/KLK7 Proteins, Antibodies, cDNA Clones Research Reagents

KLK7 (Kallikrein Related Peptidase 7, also known as hK7; SCCE; PRSS6), located on 19q13.41, is a Protein Coding gene. The gene produces a 27525 Da protein composed of 253 amino acids. KLK7 is a serine proteinase with an inhibitor profile, pH dependence, and tissue localization compatible with a role in desquamation. KLK7 belongs to the kallikrein subfamily of serine proteases, which are involved in a variety of enzymatic processes. Diseases such as Netherton Syndrome and Dermatitis are associated with KLK7. The related pathways of KLK7 include Degradation of the extracellular matrix and Collagen chain trimerization.

Kallikrein 7/KLK7 Protein (2)

    Kallikrein 7/KLK7 Antibody (5)

      Kallikrein 7/KLK7 cDNA Clone (26)


      Kallikrein 7/KLK7 Lysate (2)

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        Kallikrein 7/KLK7 Background

        Kallikrein-7, also known as kallikrein-related peptidase 7, Stratum corneum chymotryptic enzyme, Serine protease 6, KLK7, and PRSS6, is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. Members of the Kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK1), and breast cancer (KLK1, KLK13, KLK14). Kallikrein-7 / KLK7 appears to be increased in ovarian cancer and higher KLK7 expression in ovarian cancer tissue is associated with poorer prognosis of ovarian cancer patients. Kallikrein-7 / KLK7 is abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Kallikrein-7 / KLK7 is up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at the protein level). It was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). Kallikrein-7 / KLK7 may catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. KLK7 also plays a role in the activation of precursors to inflammatory cytokines.

        Kallikrein 7/KLK7 References

        • Hansson L., et al.,(1994), Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. J. Biol. Chem. 269:19420-19426.
        • Yousef G.M., et al., (2000), The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation.Gene 254:119-128.
        • Gan L., et al.,(2000), Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.Gene 257:119-130.

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