Kallikrein 13 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

KLK13 (Kallikrein Related Peptidase 13, also known as KLKL4; KLK-L4), located on 19q13.41, is a Protein Coding gene. The gene produces a 30570 Da protein composed of 277 amino acids. KLK13 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. KLK13 may be involved in the pathogenesis and/or progression of breast and ovary cancers and is regarded as a novel cancer biomarker. Diseases such as Breast Cancer are associated with KLK13. The related pathways of KLK13 include Keratinization and Collagen chain trimerization.

Kallikrein 13 Protein (1)

    Kallikrein 13 Antibody (6)

      Kallikrein 13 ELISA Kit & Match Antibody ELISA Pair Set (2)

      Kallikrein 13 cDNA Clone (26)

      NM_015596.1
      NM_001170405.1

      Kallikrein 13 Lysate (1)

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        Kallikrein 13 Background

        Tissue kallikrein 13 (hK13), also known as KLK-L4 (kallikrein-like gene 4), is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues. The KLK13 gene resides on chromosome 19q13.3-4 along with other 14 members in a gene cluster and shares a high degree of homology. KLK13 is a trypsin-like, secreted serine protease expressed specifically in the testicular tissue including prostate, salivary gland, breast, and testis. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and may play a role in metastasis. KLK13 may be involved in the pathogenesis and/or progression of breast and ovary cancers and is regarded as a novel cancer biomarker. Besides, KLK13 interacts and forms complexes with several serum protease inhibitors, such as alpha2-macroglobulin, and its expression is regulated by steroid hormones.

        Kallikrein 13 References

        • Yousef G.M., et al.,(2000), Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues. J. Biol. Chem. 275:11891-11898.
        • Komatsu N., et al., (2003), Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages.J. Invest. Dermatol. 121:542-549.
        • Andres A.M., et al.,(2007), Understanding the accuracy of statistical haplotype inference with sequence data of known phase.Genet. Epidemiol. 31:659-671.

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