IRE1 Proteins, Antibodies Research Reagents

All IRE1 reagents are produced in house and quality controlled, including 4 IRE1 Antibody, 2 IRE1 Lysate, 2 IRE1 Protein. All IRE1 reagents are ready to use.

IRE1 Protein (2)

    IRE1 Antibody (4)

      IRE1 Lysate (2)

        IRE1 Background

        Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces TP53-dependent cell growth repression and apoptosis. Thus, the expression of genes encoding TP53 and related to TP53 factors depends upon the endoplasmic reticulum stress signaling as well as on hypoxia, and correlates with suppression of glioma growth under ERN1 knockdown. The dependence of insulin-like growth binding proteins as well as IGF2BP3 and HTRA1 gene expressions in U87 glioma cells on ERN1 signaling enzyme function and hypoxia, indicating its participation in the regulation of metabolic and proliferative processes via IGF/INS receptors, because endoplasmic reticulum stress is an important component of tumor growth and metabolic diseases.

        IRE1 References

        • Trentmann,S.M. et al., 2000, Plant Mol Biol. 44 (1):11-25.
        • Iwawaki T., et al., 2001, Nat. Cell Biol. 3:158-64.
        • Liu C.Y., et al., 2003, J. Biol. Chem. 278:17680-7.
        • Oppermann F.S., et al., 2009, Mol. Cell. Proteomics 8:1751-64.

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