ING1 Antibodies, cDNA Clones Research Reagents

ING1 (Inhibitor Of Growth Family Member 1, also known as p33; p47; p33ING1; p24ING1c; p33ING1b; p47ING1a), located on 13q34, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, and frog. The gene produces a 46738 Da protein composed of 422 amino acids. This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. Diseases such as Squamous Cell Carcinoma, Head And Neck, and Squamous Cell Carcinoma are associated with ING1. The related pathways of ING1 include Chromatin Regulation / Acetylation and Senescence and Autophagy in Cancer.

ING1 Antibody (2)

    ING1 cDNA Clone (30)

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    ING1 Background

    ING1 (Inhibitor Of Growth Family Member 1) is a Protein Coding gene. This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. The ING1 gene is involved in the regulation of the cell cycle, senescence, and apoptosis and is a novel candidate tumor suppressor gene.ING1 is implicated in oncogenesis, DNA damage repair, and apoptosis. Mutations within the ING1 gene and altered expression levels of ING1 are found in multiple human cancers. Overexpression of ING1 enhances the expression of the Bax gene and was reported to alter mitochondrial membrane potential in a p53-dependent manner.

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