ILT3 Proteins, Antibodies, cDNA Clones Research Reagents

LILRB4 (Leukocyte Immunoglobulin Like Receptor B4, also known as ILT3; LIR5; CD85K; ILT-3; LIR-5), located on 19q13.42, is conserved in chimpanzee, Rhesus monkey, mouse, and rat. The gene produces a 49356 Da protein composed of 448 amino acids. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. The related pathways of LILRB4 include Innate Immune System and Class I MHC mediated antigen processing and presentation.

ILT3 Protein (5)

    ILT3 Antibody (5)

      ILT3 cDNA Clone (14)

      NM_001278426.3
      XM_015441712.1

      In cloning vector

      ILT3 Lysate (4)

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        ILT3 Background

        LILRB4 (Leukocyte Immunoglobulin Like Receptor B4) is a Protein Coding gene. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. LILRB4 is believed to down-regulate activation signals mediated by non-receptor tyrosine kinase cascades through the recruitment of SHP-1. LILRB4 is associated with the pathological processes of various inflammatory diseases. The LILRB4 is a central inhibitory receptor in Uterine dendritic cells (uDCs) that plays essential immune-regulatory roles at the maternal-fetal interface.

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