IL2RG Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL2RG (Interleukin 2 Receptor Subunit Gamma, also known as P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1), located on Xq13.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 42287 Da protein composed of 369 amino acids. The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7, and -21, and is thus referred to as the common gamma chain. Diseases such as Severe Combined Immunodeficiency, X-Linked and Combined Immunodeficiency, X-Linked are associated with IL2RG.

IL2RG Protein (7)

    IL2RG Antibody (15)

      IL2RG ELISA Kit & Match Antibody ELISA Pair Set (2)

      IL2RG cDNA Clone (52)

      NM_000206.1
      NM_013563.3
      NM_080889.1
      NM_001035529.1

      IL2RG Lysate (7)

        IL2RG Background

        The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

        IL2RG References

        • Russell SM, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 262 (5141): 1880-3.
        • Miyazaki T, et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 266 (5187): 1045-7.
        • Takeshita T, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science. 257 (5068): 379-82.

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