IL24 Proteins, Antibodies, cDNA Clones Research Reagents

IL24 (Interleukin 24, also known as C49A; FISP; MDA7; MOB5; ST16; IL10B), located on 1q32.1, is conserved in chimpanzee, dog, mouse, and rat. The gene produces a 23825 Da protein composed of 206 amino acids. This gene encodes a member of the IL10 family of cytokines. MDA7 represents a differentiation-, growth-, and apoptosis-associated gene with potential utility for the gene-based therapy of diverse human cancers. Diseases such as Melanoma and Lower Gum Cancer are associated with IL24. The related pathways of IL24 include PEDF Induced Signaling and Immune response IL-23 signaling pathway.

IL24 Protein (2)

    IL24 Antibody (2)

      IL24 cDNA Clone (39)

      BC009681
      NM_053095.2
      NM_133311.1

      IL24 Lysate (2)

        IL24 Background

        Interleukin-24 (IL-24) also known as Melanoma differentiation-associated gene 7 protein (MDA-7) is a member of the IL10 family of cytokines. IL-24/MDA-7/IL24 can induce apoptosis selectively in various cancer cells. Overexpression of IL-24 leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Human IL-24/MDA-7/IL24 is secreted by activated peripheral blood mononuclear cells and is the ligand for two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. Northern blot analysis revealed IL-24/MDA-7/IL24 expression in human tissues associated with the immune system such as the spleen, thymus, peripheral blood leukocytes, and normal melanocytes. IL-24/MDA-7/IL24 binding to either its endogenous receptors on human keratinocytes or to ectopically expressed receptors on baby hamster kidney cells leads to activation of the signal transducers and activators of transcription.

        IL24 References

        • Wang M, et al.. (2002) Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. J Biol Chem. 277(9): 7341-7.
        • Sauane M, et al.. (2003) MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine. Cytokine Growth Factor Rev. 14(1): 35-51.
        • Sarkar D, et al.. (2002) mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci U S A. 99(15): 10054-9.

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