IL23 Receptor Proteins, cDNA Clones Research Reagents

IL23R (Interleukin 23 Receptor), located on 1p31.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. The gene produces a 71722 Da protein composed of 629 amino acids. The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. IL23R does not interact with IL12, but pairs with IL12RB1 to confer IL23 responsiveness on cells expressing both subunits. Diseases such as Inflammatory Bowel Disease 17 and Psoriasis 7 are associated with IL23R. The related pathways of IL23R include the Immune response IL-23 signaling pathway and AKT Signaling Pathway.

IL23 Receptor Protein (5)

IL23 Receptor cDNA Clone (52)

BC040720
NM_144548.1
XM_002726387.1
XM_001093896.2

IL23 Receptor Lysate (5)

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    IL23 Receptor Background

    IL23R, also known as the IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK, and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells, and possibly certain macrophage/myeloid cell stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.

    IL23 Receptor References

    • Duerr RH, et al. (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 314(5804):1461-3.
    • Cargill M, et al. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 80(2):273-90.
    • Dubinsky MC, et al. (2007) IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. Inflamm Bowel Dis. 13(5):511-5.
    • Tremelling M, et al. (2007) IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology. 132(5):1657-64.

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