IL21 Proteins, Antibodies, cDNA Clones Research Reagents

IL21 (Interleukin 21, also known as Za11; IL-21; CVID11), located on 4q27, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 18653 Da protein composed of 162 amino acids. This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. Diseases such as Immunodeficiency, Common Variable, 11, and Dacryoadenitis are associated with IL21. The related pathways of IL21 include Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and PEDF Induced Signaling.

IL21 Protein (6)

    IL21 Antibody (12)

      IL21 cDNA Clone (64)

      NP_068575.1
      NM_021782.2
      NM_001108943.2
      NM_001003347.1
      NM_001194242.1

      IL21 Lysate (1)

        IL21 Background

        IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).

        IL21 References

        • Coquet JM, et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178(5):2827-34.
        • Wei L, et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 282(48):34605-10.
        • Parrish-Novak J, et al. (2002) Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72(5):856-63. 4 Kuchen S, et al. (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol. 179(9):5886-96.

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