IL20RA Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL20RA (Interleukin 20 Receptor Subunit Alpha, also known as CRF2-8; IL-20R1; IL-20RA; IL-20R-alpha), located on 6q23.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish. The gene produces a 62485 Da protein composed of 553 amino acids. It belongs to the type II cytokine receptor family. The receptor combination of IL10RB and IL20RA is unique and specific for IL26. Diseases such as Psoriasis are associated with IL20RA. The related pathways of IL20RA include Akt Signaling and PEDF Induced Signaling.

IL20RA Protein (3)

    IL20RA Antibody (8)

      IL20RA ELISA Kit & Match Antibody ELISA Pair Set (1)

      IL20RA cDNA Clone (27)

      NM_014432.2
      NM_001107521.1
      XM_541119.3

      In expression vector

      IL20RA qPCR Primer (2)

      IL20RA Lysate (3)

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        IL20RA Background

        Interleukin 20 receptor, alpha subunit (IL20RA/IL-20RA) also known as IL-20 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-20 receptor I, and interleukin-20 receptor subunit alpha, is a subunit for the interleukin-20 receptor. IL20RA/IL-20RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 20 (IL20), a cytokine that may be involved in the epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA forms heterodimer with IL20RB and the complex serves as a receptor for IL19, IL20, and IL24. All three are capable of signaling through the IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for receptor A which is recruited to complete the complex. Besides, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with the highest levels in skin, testis, and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.

        IL20RA References

        • Parrish-Novak J, et al. (2002) Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 277(49): 47517-23.
        • Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5): 445-51.
        • Blumberg H, et al. (2001) Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 104(1): 9-19.

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