IL1RAP/IL-1RAcP Proteins, Antibodies, cDNA Clones Research Reagents

IL1RAP (Interleukin 1 Receptor Accessory Protein, also known as IL1R3; C3orf13; IL-1RAcP), located on 3q28, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and frog. The gene produces a 65418 Da protein composed of 570 amino acids. This gene encodes a component of the interleukin 1 receptor complex, which initiates signaling events that result in the activation of interleukin 1-responsive genes. Diseases such as Marginal Corneal Ulcer and Indolent Myeloma are associated with IL1RAP. The related pathways of IL1RAP include Bacterial infections in CF airways and the IL-1 signaling pathway.

IL1RAP/IL-1RAcP Protein (8)

    IL1RAP/IL-1RAcP Antibody (8)

      IL1RAP/IL-1RAcP cDNA Clone (28)


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      IL1RAP/IL-1RAcP Lysate (7)

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        IL1RAP/IL-1RAcP Background

        Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces the synthesis of the acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signaling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

        IL1RAP/IL-1RAcP References

        • Goldbach-Mansky R, et al. (2009) Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses. J Allergy Clin Immunol. 124(6): 1141-9.
        • Johnston A, et al. (2011) IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. J Immunol. 186(4): 2613-22.
        • Ozaki K, et al. (2001) Effect of tumor weight and tube feeding on TNF-alpha and IL-1beta mRNA expression in the brain of mice. JPEN J Parenter Enteral Nutr. 25(6): 317-22.

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