IL1R1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL1R1 (Interleukin 1 Receptor Type 1, also known as P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha), located on 2q11.2-q12.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 65402 Da protein composed of 569 amino acids. This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. Diseases such as Schnitzler Syndrome and Cinca Syndrome are associated with IL1R1. The related pathways of IL1R1 include Monoamine Transport and Bacterial infections in CF airways.

IL1R1 Protein (9)

    IL1R1 Antibody (24)

      IL1R1 ELISA Kit & Match Antibody ELISA Pair Set (5)

      IL1R1 cDNA Clone (52)

      NM_000877.2
      NM_008362.2
      NM_013123.3
      XM_001107510.2

      IL1R1 Lysate (9)

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        IL1R1 Background

        Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

        IL1R1 References

        • Dale M, et al. (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177-9.
        • Joos L, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863-6.
        • Vigers GP, et al. (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190-4.

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